Shiyu Li

Oct 10, 2024 | mdpi.com | YING WANG |Shiyu Li

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Jun 5, 2024 | cell.com | Shiyu Li |Hui Shen |Xuehui Lyu |Kexin Lin

The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significant challenges. Here, we realize culturing human totipotent blastomere-like cells (hTBLCs).

Mar 26, 2024 | nature.com | Shiyu Li

AbstractAlthough intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) presents with persistent inflammatory stimulation of the blood vessels and an increased risk of coronary artery dilatation. However, the pathogenesis of this disease is unclear, with no established biomarkers to predict its occurrence. This study intends to explore the utility of S100A12/TLR2-related signaling molecules and clinical indicators in the predictive modeling of IVIG-resistant KD.

Dec 23, 2023 | academic.oup.com | Shiyu Li

Prostate cancer (PCa) is the second most common cancer among men, ranking fourth among all cancers in humans [1]. Conventional imaging examinations for PCa detection include computed tomography (CT), magnetic resonance imaging (MRI), as well as ultrasound [2]. MRI prostate scanning is the most sensitive imaging technique for the diagnosis of PCa; however, the specificity is limited.

Aug 7, 2023 | nature.com | Yue Qin |Yaoping Wang |Shiyu Li |Chaopeng Hong |Daniel C Gingerich |Jeffrey M. Bielicki

AbstractWater scarcity and climate change are dual challenges that could potentially threaten energy security. Yet, integrated water–carbon management frameworks coupling diverse water- and carbon-mitigation technologies at high spatial heterogeneity are largely underdeveloped.