Xuehui Lyu

Jul 1, 2024 | cell.com | Xuehui Lyu |Yingzi Cui |Yinfei Kong |Hui Shen

Highlights•DGCR8 binds to nascent mRNAs, inhibiting their transcription by sequestering FLII•Phosphorylated FLII, induced by the ERK pathway, dissociates from DGCR8 and binds to JUN•FLII facilitates JUN in activating gene expression related to cell migration•The interplay a DGCR8/FLII/JUN governs morphogenesis of implanting embryosSummaryDuring implantation, embryos undergo an unpolarized-to-polarized transition to initiate postimplantation morphogenesis.

Jun 5, 2024 | cell.com | Shiyu Li |Hui Shen |Xuehui Lyu |Kexin Lin

The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significant challenges. Here, we realize culturing human totipotent blastomere-like cells (hTBLCs).