Kheewoong Baek

Aug 31, 2023 | nature.com | Lukas T. Henneberg |Kheewoong Baek |Peter Murray |Matthias Mann |Sachdev S. Sidhu

AbstractThe cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like protein NEDD8. Assessing cellular repertoires of activated CRL complexes is critical for understanding eukaryotic regulation. However, probes surveying networks controlled by site-specific ubiquitin-like protein modifications are lacking.