Ki-Young Lee

Aug 14, 2024 | nature.com | Jung Lee |Ki-Young Lee

AbstractL-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a hematologic cancer that claims the most lives of pediatric cancer patients. Previously, we demonstrated that L-asparaginase kills aLL cells via a lethal rise in [Ca2+]i due to IP3R-mediated ER Ca2+ release followed by calpain-1-Bid-caspase-3/12 activation (Blood, 133, 2222-2232). However, upstream targets of L-asparaginase that trigger IP3R-mediated ER Ca2+ release remain elusive.

Aug 13, 2024 | onlinelibrary.wiley.com | Soo-Yeon Lee |Ki-Young Lee |Hyun-Jong Eun

1 Introduction RAS proteins (HRAS, KRAS and NRAS) are membrane-associated small GTPases and act as molecular switches that cycle between the active GTP-bound and inactive GDP-bound states, regulating multiple intracellular signaling cascades for cell proliferation, differentiation and survival.[1] The guanine nucleotide exchange factor (GEF) proteins activate RAS by catalysing the release of GDP and binding of GTP, while GTP hydrolysis is promoted by the GTPase activating proteins (GAPs).

Feb 21, 2024 | mdpi.com | Ki-Young Lee

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReviewbyKi-Young Lee Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Pocheon-si 11160, Gyeonggi-Do, Republic of KoreaInt. J. Mol. Sci.

Feb 2, 2024 | onlinelibrary.wiley.com | Soo-Yeon Lee |Ki-Young Lee

Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Jun 2, 2023 | pubmed.ncbi.nlm.nih.gov | Lee KY |Ki-Young Lee |Maristella Maggi |Claudia Scotti

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