Soo-Yeon Lee

Aug 13, 2024 | onlinelibrary.wiley.com | Soo-Yeon Lee |Ki-Young Lee |Hyun-Jong Eun

1 Introduction RAS proteins (HRAS, KRAS and NRAS) are membrane-associated small GTPases and act as molecular switches that cycle between the active GTP-bound and inactive GDP-bound states, regulating multiple intracellular signaling cascades for cell proliferation, differentiation and survival.[1] The guanine nucleotide exchange factor (GEF) proteins activate RAS by catalysing the release of GDP and binding of GTP, while GTP hydrolysis is promoted by the GTPase activating proteins (GAPs).

Feb 2, 2024 | onlinelibrary.wiley.com | Soo-Yeon Lee |Ki-Young Lee

Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.