Kimberly Smith

May 9, 2024 | jci.org | Gregory B. Waypa |Kimberly Smith |Paul T. Mungai |Vincent J. Dudley

ResearchCardiologyMetabolismOpen Access | 10.1172/JCI165482 J Clin Invest. https://doi.org/10.1172/JCI165482. Copyright © 2024, Waypa et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Dec 13, 2023 | nature.com | Xingjie Pan |Won H. Jung |Aaron R. Halpern |Kimberly Smith |Bosiljka Tasic |Zizhen Yao | +2 more

AbstractIn mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate organization of cells have impeded our understanding of the molecular and cellular basis of brain function.

Dec 13, 2023 | nature.com | Kangli Wang |Yang Xie |Michael Miller |Zhaoning Wang |Kai Zhang |Antonio Pinto-Duarte | +9 more

AbstractRecent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete1,2,3,4. Here we report a comprehensive atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain, generated by analysing chromatin accessibility in 2.3 million individual brain cells from 117 anatomical dissections.

Nov 17, 2023 | biorxiv.org | Lina Marcela Carmona |Kimberly Smith |Bosiljka Tasic |ET Thomas

AbstractCorticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse group of neurons with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, no studies have mapped the diversity of spinal cell types targeted by CSNs, let alone compare CFA and RFA populations.

Nov 17, 2023 | biorxiv.org | Lina Marcela Carmona |Kimberly Smith |Bosiljka Tasic |ET Thomas

AbstractCorticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse group of neurons with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, no studies have mapped the diversity of spinal cell types targeted by CSNs, let alone compare CFA and RFA populations.