Zizhen Yao

1 month ago | cell.com | Yoav Ben-Simon |Marcus J. Hooper |Sujatha Narayan |Tanya L. Daigle |Deepanjali Dwivedi |Sharon Way | +141 more

Keywords epigenetics transcriptomics enhancer cell type neocortex AAV transgenic recombinase mouse human Introduction To understand how the brain works, we need to establish the structure-function relationships between the units that comprise it and the outputs of its activity.1 One approach is to gain experimental access to each building block (e.g., a cell type) and manipulate it to observe effects on an animal’s physiology and behavior.2,3,4 Historically, the definition of building blocks...

Dec 13, 2023 | nature.com | Xingjie Pan |Won H. Jung |Aaron R. Halpern |Kimberly Smith |Bosiljka Tasic |Zizhen Yao | +2 more

AbstractIn mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate organization of cells have impeded our understanding of the molecular and cellular basis of brain function.

Dec 13, 2023 | nature.com | Kangli Wang |Yang Xie |Michael Miller |Zhaoning Wang |Kai Zhang |Antonio Pinto-Duarte | +9 more

AbstractRecent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete1,2,3,4. Here we report a comprehensive atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain, generated by analysing chromatin accessibility in 2.3 million individual brain cells from 117 anatomical dissections.