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2 months ago | 
nature.com | Yutao Liu |Lu Feng |Di Huang |Kai Zhang |Lei Wang
AbstractSuccinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence. Here we used SILAC-based proteomics and characterized the EHEC succinylome to show that the transcription factor, PurR, is succinylated at K24 and K55.
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Jan 20, 2025 | 
advanced.onlinelibrary.wiley.com | Jixuan Yi |Ronghao Lyu |Yiwen Li |Kai Zhang
Kai Zhang School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081 China Tangshan Research Institute, Beijing Institute of Technology, Tangshan, 063000 ChinaSearch for more papers by this author
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Jan 15, 2025 | 00039-0/fulltext&sz=64)
jbc.org | Kai Zhang
Research ArticleArticles in Press108192Open accessDepartment of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, 300070 Tianjin, P. R.
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Jan 14, 2025 | 
mdpi.com | Yuan Zhao |Yu An Zhang |Kai Zhang |Jiashu Tian
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Dec 19, 2024 | 
mdpi.com | Kai Zhang
1. IntroductionAccording to the 2019 World Population Prospects, by 2050, it is anticipated that the global older adult population (>60) will double [1]. The number of persons aged 80 years or older is expected to triple between 2020 and 2050, reaching 426 million [1]. Further, it was estimated that one in six people globally will be over the age of 65, up from one in eleven in 2019 [2].
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Dec 4, 2024 | 
onlinelibrary.wiley.com | Kai Zhang |Dan Li
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Nov 11, 2024 | 
onlinelibrary.wiley.com | Yan Chen |Kai Zhang
CONFLICT OF INTEREST STATEMENT The authors have no conflict of interests to declare that are relevant to the content of this article. REFERENCES 1, , , and , Learning theories: views from behaviourism theory and constructivism theory, Int. J. Acad. Res. Prog. Educ. Dev. 10 (2021), no. 1, 85–98.
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Oct 21, 2024 | 
onlinelibrary.wiley.com | Jixuan Yi |Ronghao Lyu |Yiwen Li |Kai Zhang
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202413789-sup-0001-SuppMat.docx2.3 MB Supporting Information adfm202413789-sup-0002-VideoS1.mp421.2 MB Supplemental Video 1 adfm202413789-sup-0003-VideoS2.mp433.2 MB Supplemental Video 2 adfm202413789-sup-0004-VideoS3.mp419.7 MB Supplemental Video 3 References 1, , , , , , , , , Adv. Sci. 2023, 10, 2302475. 2, , , Adv. Funct. Mater. 2023, 33, 2213371.
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Oct 21, 2024 | 
pericles.pericles-prod.literatumonline.com | Yiwen Li |Kai Zhang |Jixuan Yi |Ronghao Lyu
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202413789-sup-0001-SuppMat.docx2.3 MB Supporting Information adfm202413789-sup-0002-VideoS1.mp421.2 MB Supplemental Video 1 adfm202413789-sup-0003-VideoS2.mp433.2 MB Supplemental Video 2 adfm202413789-sup-0004-VideoS3.mp419.7 MB Supplemental Video 3 References 1, , , , , , , , , Adv. Sci. 2023, 10, 2302475. 2, , , Adv. Funct. Mater. 2023, 33, 2213371.
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Oct 18, 2024 | 
onlinelibrary.wiley.com | Yanmin Wang |Engineering Beijing |Wei Guo |Kai Zhang
1 Introduction Bacterial infections remain a significant global health concern, and the emergence of antibiotic-resistant bacteria has led to an urgent need for novel non-antibiotic treatment strategies.[1] Tremendous observations have manifested that reactive oxygen species (ROS) – mediated therapeutic methods demonstrate potential in antibacterial therapy, as ROS are highly reactive molecules that are able to damage cell membranes, DNA, and proteins, ultimately leading to bacterial...
