Klaus J. Stark

Nov 28, 2024 | genomebiology.biomedcentral.com | Thomas Winkler |Simon Wiegrebe |Janina M. Herold |Klaus J. Stark |Helmut Küchenhoff |Iris M Heid

The UKB included approximately 500,000 individuals from the UK aged 40–69 years. The samples were genotyped based on the Affymetrix UKB Axiom Array and then imputed to the Haplotype Reference Consortium and the UK10K haplotype resource [41]. We restricted our analysis sample to individuals of European population using the population definitions generated by the PAN-UKB project (https://pan.ukbb.broadinstitute.org/).

Nov 19, 2024 | nature.com | Simon Wiegrebe |Mathias Gorski |Klaus J. Stark |Christian Gieger |Johannes Schödel |Han Chen | +3 more

AbstractUnderstanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We use longitudinal UK Biobank data for creatinine-based estimated glomerular filtration rate from 348,275 individuals to search for genetic variants associated with eGFR-decline. This search was performed both among 595 variants previously associated with eGFR in cross-sectional GWAS and genome-wide.