Kristin G. Beaumont

Sep 10, 2024 | nature.com | Jens Chr. Hansen |Yuguang Xiong |Kristin G. Beaumont |Robert Sebra |James Gallo |Marc R. Birtwistle | +5 more

AbstractDrug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic profiles. We use singular value decomposition to identify drug-selective patterns across cell lines obtained from multiple healthy human subjects.