Robert Sebra

Sep 10, 2024 | nature.com | Jens Chr. Hansen |Yuguang Xiong |Kristin G. Beaumont |Robert Sebra |James Gallo |Marc R. Birtwistle | +5 more

AbstractDrug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic profiles. We use singular value decomposition to identify drug-selective patterns across cell lines obtained from multiple healthy human subjects.

Jan 19, 2024 | nature.com | Matthew D. Galsky |Sudeh Izadmehr |Edgar Gonzalez-Kozlova |Kevin Chan |Christos E. Kyriakopoulos |Mahalya Gogerly-Moragoda | +5 more

Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02568-1, published online 2 October 2023. In the version of the article initially published, Diane M.

Oct 2, 2023 | nature.com | Matthew D. Galsky |Sudeh Izadmehr |Edgar Gonzalez-Kozlova |Kevin Chan |Christos E. Kyriakopoulos |Robert M. Samstein | +5 more

AbstractCystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering. We initiated a phase 2 study in which patients with MIBC received four cycles of gemcitabine, cisplatin, plus nivolumab followed by clinical restaging. Patients achieving a clinical complete response (cCR) could proceed without cystectomy.

Mar 11, 2023 | nature.com | Robert Sebra

In this work, we presented UniCell: Deconvolve Base, a universal, context-free cell type deconvolution tool for transcriptomic data that integrates the entirety of publicly-available scRNA-Seq data into a single unified training dataset for deep learning applications.