Marc R. Birtwistle

Sep 10, 2024 | nature.com | Jens Chr. Hansen |Yuguang Xiong |Kristin G. Beaumont |Robert Sebra |James Gallo |Marc R. Birtwistle | +5 more

AbstractDrug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic profiles. We use singular value decomposition to identify drug-selective patterns across cell lines obtained from multiple healthy human subjects.

Jun 3, 2024 | nature.com | Alan Stern |Marc R. Birtwistle

AbstractUnderstanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular processes and diseases, particularly cancer. While previous studies have established associations between ERK and Akt activities and proliferative cell fate, the heterogeneity of single-cell responses adds complexity to this understanding.

Jan 20, 2024 | biorxiv.org | Alan Stern |Xiang Zhang |Marc R. Birtwistle |Gaurav Pandey

AbstractUnderstanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular processes and diseases, particularly cancer. While previous studies have established associations between ERK and Akt activities and proliferative cell fate, the heterogeneity of single-cell responses adds complexity to this understanding.