Kristina M. Kruglyak

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Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs

Jul 11, 2023 | mdpi.com | Kristina M. Kruglyak |Allison L. O’Kell |Todd Cohen |Maggie Marshall

4. DiscussionThe identification of recurrent CNVs in the WBC gDNA of older dogs, which persist with little to no change in amplitude over time and are absent from cfDNA (and from tumor tissue, in dogs with concurrent cancer), provides early evidence for the existence of age-related somatic alterations in dogs that resemble the phenomenon of CHIP previously described in humans.
Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients (pdf) | Paperity

Mar 26, 2023 | paperity.org | Jill Rafalko |Kristina M. Kruglyak |Angela L. McCleary-Wheeler |Vidit Goyal

PLOS ONE, Feb 2023 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280795&type=printable Jill M. Rafalko, Kristina M. Kruglyak, Angela L. McCleary-Wheeler, Vidit Goyal, Ashley Phelps-Dunn, Lilian K. Wong, Chelsea D. Warren, Gina Brandstetter, Michelle C. Rosentel, Lauren DiMarzio, Lisa M. McLennan, Allison L. O’Kell, Todd A. Cohen, Daniel S. Grosu, Jason Chibuk, Dana W. Y.

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