Kubra F. Naqvi

Nov 28, 2023 | biorxiv.org | Tan-Yun Cheng |Kubra F. Naqvi |Lindsay E. Guzman |CJ Cambier

AbstractSurface lipids on pathogenic mycobacteria modulate infection outcomes by regulating host immune responses. Phenolic glycolipid (PGL) is a host-modulating surface lipid that varies among clinical Mycobacterium tuberculosis strains. PGL is also found in Mycobacterium marinum where it promotes infection of zebrafish through effects on the innate immune system.

Nov 28, 2023 | dx.doi.org | Lindsay E. Guzman |C. J. Cambier |Tan-Yun Cheng |Kubra F. Naqvi

Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Chem. Biol. 2024, XXXX, XXXRETURN TO ARTICLES ASAPPREVArticlesNEXTLindsay E. GuzmánStanford Sarafan ChEM-H, Stanford University, Stanford, California 94305, United StatesDepartment of Chemistry, Stanford University, Stanford, California 94305, United States, C. J.

Oct 28, 2023 | nature.com | Kubra F. Naqvi

AbstractTherapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease. A murine model of TB relapse was used to identify changes in Th populations and cytokine microenvironment. Active TB promoted expansion of Th1, Th2, Th17, and Th22 cells and cytokines in the lung.