Kunal Raygor

Dec 4, 2024 | biorxiv.org | Xuetao Zhang |Kyle Jacobs |Kunal Raygor |Shang Li

AbstractHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. HHT pathogenesis is thought to follow a Knudsonian two-hit model, requiring a second somatic mutation for lesion formation.

Nov 28, 2024 | biorxiv.org | Xuetao Zhang |Kyle Jacobs |Kunal Raygor |Shang Li

AbstractHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with presentations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. Mutations in activin receptor-like kinase 1 (ALK1) gene cause HHT type 2.