Kyle Jacobs

Dec 4, 2024 | biorxiv.org | Xuetao Zhang |Kyle Jacobs |Kunal Raygor |Shang Li

AbstractHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. HHT pathogenesis is thought to follow a Knudsonian two-hit model, requiring a second somatic mutation for lesion formation.

Nov 28, 2024 | biorxiv.org | Xuetao Zhang |Kyle Jacobs |Kunal Raygor |Shang Li

AbstractHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with presentations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited bleeding disorder, the pathophysiological mechanism underlying HHT-associated hemorrhage is poorly understood. Mutations in activin receptor-like kinase 1 (ALK1) gene cause HHT type 2.

Sep 30, 2024 | nature.com | Elizabeth Crouch |Kyle Jacobs |Lakyn Mayo |Jennifer Choi |Saba Shaikh |Arnold R. Kriegstein | +4 more

AbstractGerminal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture remains unknown. Here we show that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduces angiogenesis in the ganglionic eminences, which correspond to the human germinal matrix.

Oct 5, 2023 | rupress.org | Matthew White |Kyle Jacobs |Lakyn Mayo

Notch receptors control tissue morphogenic processes that involve coordinated changes in cell architecture and gene expression, but how a single receptor can produce these diverse biological outputs is unclear. Here, we employ a 3D model of a human ductal epithelium to reveal tissue morphogenic defects result from loss of Notch1, but not Notch1 transcriptional signaling.