Lai Guan Ng

Jun 21, 2024 | nature.com | Yahui Long |Kok Siong Ang |Raman Sethi |Lynn van Olst |Hang Xu |Lai Guan Ng | +3 more

AbstractAdvances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integration. Here, we introduce SpatialGlue, a graph neural network model with a dual-attention mechanism that deciphers spatial domains by intra-omics integration of spatial location and omics measurement followed by cross-omics integration.