Kok Siong Ang

Dec 4, 2024 | biorxiv.org | Xuhua Yan |Kok Siong Ang |Lynn van Olst |Alex Edwards

AbstractWith the advent of spatial multi-omics, we can mosaic integrate diverse datasets with partially overlapping modalities to construct consensus multi-modal spatial atlases of the source tissue. SpaMosaic is a spatial multi-omics mosaic integration tool that employs contrastive learning and graph neural networks to construct a modality-agnostic and batch-corrected latent space suited for analyses like spatial domain identification and imputing missing omes.

Oct 14, 2024 | flipboard.com | Kok Siong Ang |Jinmiao Chen |Chengwei Zhong

3 hours agoBut there is something you can do about it, according to the experts. Many people consider eyebrows to be a frame for the face, but ... wait, did my frame just fall off the wall? If you’re suddenly getting much more familiar— and heavy-handed — with your eyebrow pencil, it might be because your …

Oct 3, 2024 | biorxiv.org | Kok Siong Ang |Lynn van Olst |Alex Edwards |Xuhua Yan

AbstractWith the advent of spatial multi-omics, we can mosaic integrate such datasets with partially overlapping modalities to construct higher dimensional views of the source tissue. SpaMosaic is a spatial multi-omics mosaic integration tool that employs contrastive learning and graph neural networks to construct a modality-agnostic and batch-corrected latent space suited for analyses like spatial domain identification and imputing missing omes.

Jun 21, 2024 | nature.com | Yahui Long |Kok Siong Ang |Raman Sethi |Lynn van Olst |Hang Xu |Lai Guan Ng | +3 more

AbstractAdvances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integration. Here, we introduce SpatialGlue, a graph neural network model with a dual-attention mechanism that deciphers spatial domains by intra-omics integration of spatial location and omics measurement followed by cross-omics integration.