Lara Rosaline Heij

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Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

Apr 6, 2024 | biorxiv.org | Lara Rosaline Heij |Sikander Hayat |Konrad Reichel |Sidrah Maryam

AbstractBackground and aims: Cholangiocarcinoma (CCA) is a deadly disease, and this cancer entity is characterized by an abundant stroma. The tumor microenvironment (TME) plays an important role in aggressive behavior and poor response to therapeutics; however, underlying pathways are unknown.
Shift in cellular crosstalk reveals the immunosuppressive environment in cholangiocarcinoma patients.

Feb 7, 2024 | biorxiv.org | Lara Rosaline Heij |Sikander Hayat |Konrad Reichel |Sidrah Maryam

AbstractObjective: Cholangiocarcinoma (CCA) is a deadly disease, and treatment options besides surgery are limited. This cancer entity is characterized by abundant stroma and the tumor microenvironment (TME) plays an important role in the poor response rate to therapeutics; however, underlying pathways are unknown.

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