Sidrah Maryam

Sep 17, 2024 | jci.org | Konrad Hoeft |Lars Koch |Susanne Ziegler |Ling Zhang |Maria C. Tanzer |David Schumacher | +10 more

AbstractFibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis.

Apr 6, 2024 | biorxiv.org | Lara Rosaline Heij |Sikander Hayat |Konrad Reichel |Sidrah Maryam

AbstractBackground and aims: Cholangiocarcinoma (CCA) is a deadly disease, and this cancer entity is characterized by an abundant stroma. The tumor microenvironment (TME) plays an important role in aggressive behavior and poor response to therapeutics; however, underlying pathways are unknown.

Feb 7, 2024 | biorxiv.org | Lara Rosaline Heij |Sikander Hayat |Konrad Reichel |Sidrah Maryam

AbstractObjective: Cholangiocarcinoma (CCA) is a deadly disease, and treatment options besides surgery are limited. This cancer entity is characterized by abundant stroma and the tumor microenvironment (TME) plays an important role in the poor response rate to therapeutics; however, underlying pathways are unknown.