Laura Isigkeit

Jun 17, 2024 | nature.com | Laura Isigkeit |Lorène Brunello |Amelie Menge |Susanne Müller |Stefan Knapp |Alexandra Stolz

AbstractNuclear receptors (NRs) regulate transcription in response to ligand binding and NR modulation allows pharmacological control of gene expression. Although some NRs are relevant as drug targets, the NR1 family, which comprises 19 NRs binding to hormones, vitamins, and lipid metabolites, has only been partially explored from a translational perspective.