Lorène Brunello

Nov 25, 2024 | nature.com | Martin P. Schwalm |Johannes Dopfer |Adarsh Kumar |Francesco Greco |Nicolas Bauer |Frank Lohr | +18 more

AbstractRecent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development community.

Jun 17, 2024 | nature.com | Laura Isigkeit |Lorène Brunello |Amelie Menge |Susanne Müller |Stefan Knapp |Alexandra Stolz

AbstractNuclear receptors (NRs) regulate transcription in response to ligand binding and NR modulation allows pharmacological control of gene expression. Although some NRs are relevant as drug targets, the NR1 family, which comprises 19 NRs binding to hormones, vitamins, and lipid metabolites, has only been partially explored from a translational perspective.

Dec 14, 2023 | nature.com | Rayene Berkane |Hung Ho-Xuan |Marius Glogger |Lorène Brunello |Santosh Kumar Kuncha |Ashwin Balakrishnan | +8 more

AbstractSelective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a critical role during stress-induced ER-phagy. However, the mechanisms on how they are activated remain largely unknown.