Leyun Wang

Apr 24, 2024 | nature.com | Jiaqiang Wang |Yiwei Zhang |Guihai Feng |Falong Lu |Leyun Wang |Wei Li | +1 more

AbstractThe heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown. Here, we show that Carm1 mRNA is of a variety of specific exon-skipping splicing (ESS) isoforms in mouse two-cell to four-cell embryos that contribute to CARM1 heterogeneity. Disruption of paraspeckles promotes the ESS of Carm1 precursor mRNAs (pre-mRNAs).