Jiaqiang Wang

Sep 24, 2024 | mdpi.com | Fuqing Li |Caiyun Yin |Zhen Li |Jiaqiang Wang

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Jul 31, 2024 | mdpi.com | Peng Yin |Yang Guo |Man Zhang |Jiaqiang Wang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Apr 24, 2024 | nature.com | Jiaqiang Wang |Yiwei Zhang |Guihai Feng |Falong Lu |Leyun Wang |Wei Li | +1 more

AbstractThe heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown. Here, we show that Carm1 mRNA is of a variety of specific exon-skipping splicing (ESS) isoforms in mouse two-cell to four-cell embryos that contribute to CARM1 heterogeneity. Disruption of paraspeckles promotes the ESS of Carm1 precursor mRNAs (pre-mRNAs).