Li Zhang

1 week ago | nature.com | Li Zhang

AbstractThere is limited understanding of the phenomenon of reversible drug resistance, which is characterized by tumor cells regaining sensitivity when the drug is changed or withdrawn after a period of drug resistance. This phenomenon is usually not associated with genetic alterations of tumor cells. In this study, reversible resistant state was induced by alectinib in EML4-ALK mutant lung cancer cell.

2 weeks ago | nature.com | Ying Cheng |Jun Liao |Jordi Rodon |Yongsheng Li |Yun Fan |Jin Billy Li | +1 more

AbstractTrophoblast cell-surface antigen 2 (TROP2)-directed antibody–drug conjugate (ADC) is a promising anticancer agent that has shown remarkable efficacy in several malignancies. However, in lung cancer, two phase 3 trials on TROP2-ADCs in unselected patients with advanced non-small-cell lung cancer (NSCLC) have both failed. Sacituzumab tirumotecan (sac-TMT) is a novel TROP2-directed ADC.

2 weeks ago | mdpi.com | Li Zhang |Ping Yuan |Yingjie Ding

1. IntroductionThe Sustainable Development Goals (SDGs) include improving the inclusiveness, safety, resilience, and sustainability of cities and human communities [1] (Figure 1). Designing sustainable and appropriate shared outdoor spaces can increase the inclusiveness and resilience of cities [2]. N. Abdollahzadeh and J. Rodríguez-Algeciras et al.

2 weeks ago | journals.plos.org | Mengmeng Yu |Li Zhang |Ying Wang |Suyan Wang |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Yu M, Zhang L, Wang Y, Wang S, Liu Y, Liu P, et al. (2025) N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling. PLoS Pathog 21(4): e1013064. https://doi.org/10.1371/journal.ppat.1013064Editor: Richard A.

2 weeks ago | mdpi.com | Guangpeng Zhang |Li Zhang |Alim Samat |Yin Chao Wu

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