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3 weeks ago | 
pubs.acs.org | Ziyu Li |Peng R. Chen |Lei Wang |Yumeng Zhang
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1 month ago | 
dovepress.com | Qin Wang |Lei Wang |Li Zhang |Chongyang Zhao
Qin Wang,1,2,* Lei Wang,2,* Li Zhang,2 Chongyang Zhao,1 Ying Liu,2 Lei Liu,2 Lishan Yuan,2 Min Feng,3,4 Gang Wang,5 Li Li,1 Shuwen Zhang,6 Yulai Yuan,7 Deying Kang,1,8 Xin Zhang2 1Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic...
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1 month ago | 
onlinelibrary.wiley.com | Shan Gao |Lei Wang |Nan Zhang |Yu Qing Bai
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES , , & (2022). Improving the tactical scanning of student pilots: A gaze-based training intervention for transition from visual flight into instrument meteorological conditions. Applied Ergonomics, 100, 103642. , , , , & (2016). How drivers fail to avoid crashes: A risk-homeostasis/perception-response (RH/PR) framework evidenced by visual perception, electrodermal activity and behavioral responses.
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2 months ago | 
nature.com | Xin Li |Huadong Guo |Guodong Cheng |Youhua Ran |Min Feng |Tao Che | +5 more
AbstractAs important components of global commons, environmental changes in polar regions are crucial to the local and global sustainability. However, they have received little attention in the current framework of sustainable development goals (SDGs). This study examines the impacts of climate change in polar regions, emphasizing the interconnectedness of these areas with other parts of the global system.
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2 months ago | 
onlinelibrary.wiley.com | Zhenyan Zhang |Lei Wang |Qing Yu |Jing Li
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202501298-sup-0001-SuppMat.docx4.8 MB Supporting Information References 1a) , , , Clin. Microbiol. Infect. 2020, 26, 142; b) , , , , PLoS Pathog. 2018, 14, 1007112; c) , , , , , , , , J. Am. Med. Assoc. 2014, 311, 1317. 2, , , , , , , , , Proc. Natl. Acad. Sci. USA 1990, 87, 225. 3, , , , , , , , , , , , Adv. Funct. Mater. 2024, 34, 2402785. 4a) , , , Clin. Infect. Dis.
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Mar 4, 2025 | 
mdpi.com | Yuan Yuan |Guowei Zhao |JIng Lu |Lei Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Feb 1, 2025 | 
nature.com | Shenghong Liu |Wenwen Gao |Lei Wang |Na Liu |Shiying Zhang |Lingyun Cheng | +2 more
Defocus incorporated multiple segment (DIMS) lenses and repeated low-level red-light (RLRL) are used to retard myopia progression. However, it is currently unknown if there is a synergistic effect of the two interventions. In the current study, 190 school-aged children with myopia (380 eyes) were studied for the change in axial length (AL) over nearly one year of follow-up. Of 380 eyes, 170 eyes wore DIMS lenses, 80 eyes had RLRL therapy, and 130 eyes had both interventions (DIMS_RLRL) for myopia control. AL changes were calculated at each follow-up visit by subtracting the baseline measurements and normalized to yearly changes in mm. AL changes as a primary outcome were analyzed in a generalized linear mixed model to compare effect sizes of myopia control among three interventions while adjusting for age, sex, baseline axial length, and follow-up length. Participants had a mean age of 9.84 ± 2.63 years old, mean AL of 24.49 ± 1.20 mm, mean SER of -2.90 ± 2.08 diopters, and mean follow-up time of 301 ± 91 days. By the end of the study, the adjusted mean yearly axial change with combination therapy was − 0.13 mm, -0.04 mm for the eyes with RLRL alone, and 0.16 mm for the eyes with DIMS lenses alone (p < 0.0001). Combination therapy of DIMS and RLRL has significantly greater effect size in controlling myopia progression than either RLRL alone (p = 0.0009) or DIMS alone (p < 0.0001).
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Jan 30, 2025 | 
nature.com | Yutao Liu |Lu Feng |Di Huang |Kai Zhang |Lei Wang
AbstractSuccinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence. Here we used SILAC-based proteomics and characterized the EHEC succinylome to show that the transcription factor, PurR, is succinylated at K24 and K55.
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Jan 24, 2025 | 
biorxiv.org | Lei Wang |Kai Kang |Chen Song
AbstractMembrane proteins play pivotal roles in cellular signaling and transport, making them prime targets for therapeutic intervention. Therefore, expeditious screening and accurate property prediction of these proteins is crucial. Recently, we proposed a new metric, the membrane contact probability (MCP), to characterize the membrane-contacting features of membrane proteins and further refine the prediction of the relative accessibility of proteins (ProtRAP).
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Jan 13, 2025 | 
mdpi.com | Xu Liu |Zhongfang Yang |Zhiliang Wu |Lei Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
