Lei Wang

1 week ago | onlinelibrary.wiley.com | Zhenyan Zhang |Lei Wang |Qing Yu |Jing Li

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202501298-sup-0001-SuppMat.docx4.8 MB Supporting Information References 1a) , , , Clin. Microbiol. Infect. 2020, 26, 142; b) , , , , PLoS Pathog. 2018, 14, 1007112; c) , , , , , , , , J. Am. Med. Assoc. 2014, 311, 1317. 2, , , , , , , , , Proc. Natl. Acad. Sci. USA 1990, 87, 225. 3, , , , , , , , , , , , Adv. Funct. Mater. 2024, 34, 2402785. 4a) , , , Clin. Infect. Dis.

1 month ago | mdpi.com | Yuan Yuan |Guowei Zhao |JIng Lu |Lei Wang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

2 months ago | nature.com | Shenghong Liu |Wenwen Gao |Lei Wang |Na Liu |Shiying Zhang |Lingyun Cheng | +2 more

Defocus incorporated multiple segment (DIMS) lenses and repeated low-level red-light (RLRL) are used to retard myopia progression. However, it is currently unknown if there is a synergistic effect of the two interventions. In the current study, 190 school-aged children with myopia (380 eyes) were studied for the change in axial length (AL) over nearly one year of follow-up. Of 380 eyes, 170 eyes wore DIMS lenses, 80 eyes had RLRL therapy, and 130 eyes had both interventions (DIMS_RLRL) for myopia control. AL changes were calculated at each follow-up visit by subtracting the baseline measurements and normalized to yearly changes in mm. AL changes as a primary outcome were analyzed in a generalized linear mixed model to compare effect sizes of myopia control among three interventions while adjusting for age, sex, baseline axial length, and follow-up length. Participants had a mean age of 9.84 ± 2.63 years old, mean AL of 24.49 ± 1.20 mm, mean SER of -2.90 ± 2.08 diopters, and mean follow-up time of 301 ± 91 days. By the end of the study, the adjusted mean yearly axial change with combination therapy was − 0.13 mm, -0.04 mm for the eyes with RLRL alone, and 0.16 mm for the eyes with DIMS lenses alone (p < 0.0001). Combination therapy of DIMS and RLRL has significantly greater effect size in controlling myopia progression than either RLRL alone (p = 0.0009) or DIMS alone (p < 0.0001).

2 months ago | nature.com | Yutao Liu |Lu Feng |Di Huang |Kai Zhang |Lei Wang

AbstractSuccinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence. Here we used SILAC-based proteomics and characterized the EHEC succinylome to show that the transcription factor, PurR, is succinylated at K24 and K55.

Jan 24, 2025 | biorxiv.org | Lei Wang |Kai Kang |Chen Song

AbstractMembrane proteins play pivotal roles in cellular signaling and transport, making them prime targets for therapeutic intervention. Therefore, expeditious screening and accurate property prediction of these proteins is crucial. Recently, we proposed a new metric, the membrane contact probability (MCP), to characterize the membrane-contacting features of membrane proteins and further refine the prediction of the relative accessibility of proteins (ProtRAP).