Liangjing Wang

Jan 9, 2025 | nature.com | Chengyu Shi |Shanshan Xie |Qiang Sun |Lingjie Sang |Wei Zhuo |Jian Liu | +8 more

AbstractThe systematic identification and functional characterization of noncanonical translation products, such as novel peptides, will facilitate the understanding of the human genome and provide new insights into cell biology. Here, we constructed a high-coverage peptide sequencing reference library with 11,668,944 open reading frames and employed an ultrafiltration tandem mass spectrometry assay to identify novel peptides.

Feb 17, 2023 | nature.com | Qiang Sun |Lisong Teng |Liangjing Wang |Wei Liu |Wei Zhuo

AbstractLiver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis.