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Nov 27, 2024 | 
link.springer.com | Liangzhu Laboratory
Correction to: Experimental & Molecular Medicine https://doi.org/10.1038/s12276-024-01346-4, published online 08 November 2024In this article, Jiali Gong, Xiawei Li, Zengyu Feng, and Jianyao Lou should have been denoted as equally contributing authors. The original article has been corrected.
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Nov 18, 2024 | 00637-3&sz=64)
cell.com | Liangzhu Laboratory
Keywordslysosomal signalingtotipotency2-cell-like cellsretrotransposonsGet full text accessLog in, subscribe or purchase for full access. References1. Ishiuchi, T. ∙ Torres-Padilla, M.E.Towards an understanding of the regulatory mechanisms of totipotencyCurr. Opin. Genet. Dev. 2013; 23:512-5182. Lu, F. ∙ Zhang, Y. Cell totipotency: molecular features, induction, and maintenanceNatl. Sci. Rev. 2015; 2:217-2253. Xiong, Z. ∙ Xu, K. ∙ Lin, Z. ...
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Nov 14, 2024 | 00227-7?rss=yes&sz=64)
cell.com | Liangzhu Laboratory |Haoxing Xu
KeywordscGASSTINGTFEBlysosomeGet full text accessLog in, subscribe or purchase for full access. References1. Liu, S. ... Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationScience. 2015; 347, aaa26302. Wang, A. ... Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disordersNat. Cell Biol. 2024; 26:219-2343. Ballabio, A. ∙ Bonifacino, J.S.Lysosomes as dynamic regulators of cell and organismal homeostasisNat. Rev. Mol. Cell Biol.
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Sep 19, 2024 | 00244-3?rss=yes&sz=64)
cell.com | Xudong WANG |Liangzhu Laboratory |Jin Zhang
References1. Cassetta, L. ∙ Pollard, J.W.Targeting macrophages: therapeutic approaches in cancerNat. Rev. Drug Discov. 2018; 17:887-9042. Pate, K.T. ... Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancerEMBO J. 2014; 33:1454-14733. Wang, S. ... Metabolic reprogramming of macrophages during infections and cancerCancer Lett. 2019; 452:14-224. Qian, B.Z. ∙ Pollard, J.W.Macrophage diversity enhances tumor progression and metastasisCell. 2010; 141:39-515. Condeelis, J.
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Jun 10, 2024 | 
diabetesjournals.org | Liangzhu Laboratory
Insulin replacement therapy is indispensable in the treatment of type 1 and advanced type 2 diabetes. However, insulin’s clinical application is challenging due to its narrow therapeutic index. To mitigate acute and chronic risks of glucose excursions, glucose-responsive insulin (GRI) has long been pursued for clinical application.
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May 14, 2024 | 
genomemedicine.biomedcentral.com | Liangzhu Laboratory
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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May 13, 2024 | 00286-1?rss=yes&sz=64)
cell.com | Qinqin Cui |Zongyu Liu |Ge Bai |Liangzhu Laboratory
Alberts B. Johnson A. Lewis J. Raff M. Roberts K. Walter P. Molecular Biology of the Cell. Fifth Edition. W.W. Norton & Company, 2007https://doi.org/10.1201/9780203833445Hirose T. Ninomiya K. Nakagawa S. Yamazaki T. A guide to membraneless organelles and their various roles in gene regulation. Nat. Rev. Mol. Cell Biol. 2023; 24: 288-304https://doi.org/10.1038/s41580-022-00558-8Brangwynne C.P. Eckmann C.R. Courson D.S. Rybarska A. Hoege C. Gharakhani J. Jülicher F.
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Apr 4, 2024 | 
link.springer.com | Liangzhu Laboratory
AbstractThe ubiquitin–proteasome system (UPS) has a critical role in post-translational protein modification that is essential for the maintenance of all cellular functions, including immune responses. The proteasome complex is ubiquitously expressed and is responsible for degradation of short-lived structurally abnormal, misfolded and not-needed proteins that are targeted for degradation via ubiquitin conjugation.
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Apr 4, 2024 | 00393-0&sz=64)
cell.com | Liangzhu Laboratory
Highlights•Screening of chromatin-modifying drugs identifies class I HDACi as boosters of CAR-T cells•Class I HDACi enhance persistence and in vivo antitumor efficacy of CAR-T cells•Class I HDACi decrease HDAC1 expression and enhance H3K27ac activity•Multi-omics reveal class I HDACi activating the Wnt pathway in CAR-T cellsSummaryEpigenetic modification shapes differentiation trajectory and regulates the exhaustion state of chimeric antigen receptor T (CAR-T) cells.
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Jan 7, 2024 | 
genomemedicine.biomedcentral.com | Liangzhu Laboratory
We ensemble several germline mutation databases as the source of our datasets. Germline mutations are changes to DNA that individuals inherit from the egg and sperm cells during conception. ClinVar database (https://ftp.ncbi.nlm.nih.gov/pub/clinvar/, accessed 2022.6.24) was downloaded and included nonsynonymous SNV (missense variants), stop-gain variants, start-loss variants, frameshift mutations, nonframeshift mutations, and stop-loss variants [4].
