Lien Nguyen

1 week ago | science.org | Lien Nguyen |Wei Wong

Editors' ChoiceMETABOLISMWei Wong https://orcid.org/0009-0008-7154-4108 [email protected] Info & AffiliationsAbstractCovalent protein modification with endogenously produced cyanide supports mammalian cell proliferation. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Many biologically necessary substances become toxic at excessive amounts. Zuhra et al.

1 week ago | science.org | Lien Nguyen |Wei Wong |Satyaki Sengupta |Kevin Cho

Editor’s summaryNeuroblastoma is a pediatric cancer that originates from progenitor cells arising from the neural crest. A subtype of this cancer is characterized by the presence of immature mesenchymal (MES) cells, which are resistant to standard treatments, including retinoic acid therapy. Nguyen et al. screened small-molecule activators of the microRNA miR-124, which drives differentiation in neuroblastoma cells, and identified PP121, a drug that inhibits tyrosine and phosphoinositide kinases.