Wei Wong

A recent study decodes how #obesity disrupts the liver’s ability to metabolically adapt to starvation in mice, potentially explaining how obesity can negate the benefits of intermittent fasting and other forms of dietary restriction. @UTokyo_News_en https://t.co/e9m9NcFzes https://t.co/Mfolzo3alo

In this week’s Editors’ Choice piece, we highlight a study by Tang and colleagues in @MolecularCell, showing that the innate immunity mediator STING senses and repairs lysosomal dysfunction. Read a summary: https://t.co/aVm1DHCgaU https://t.co/55WEQNyktH

How do pericytes adjust blood flow in the brain? Using microscopy in mice, scientists observe that pericytes at arteriole-capillary segments constrict in response to rising blood pressure through activation of TRPC3 and calcium channels. @CUSOMAnesthesia https://t.co/RpZ1pnBr1g https://t.co/zudTwc3yfK

Researchers build an intracellular profile of dormancy in aggressive #BreastCancer cells and show that OVOL transcription factors support dormancy and survival by stimulating selective #autophagy and suppressing antioxidant signaling. @WeizmannScience https://t.co/3s0BTIV7VQ https://t.co/q4beFqxTFW

In this issue's Editors’ Choice piece, we highlight a study by Gomes and colleagues in @nchembio, which used top-down proteomics to better characterize the proteome of breast cancer cells. Read a summary: https://t.co/CKSKhasP0K https://t.co/p7JnaWTbXl

A new study decodes how #obesity disrupts the liver’s ability to metabolically adapt to starvation in mice, potentially explaining how obesity can negate the benefits of intermittent fasting and other forms of dietary restriction. @UTokyo_News_en https://t.co/e9m9NcFzes https://t.co/IH7qEX3rdw

Scientists have made new discoveries about how the “pruning” of synapses influences the landscape of proteins within #neurons, providing a foundation from which to explore the development of neuromuscular junctions (#NMJs). @BioMedSciEd https://t.co/Oiu7mDc8cq https://t.co/LS8mkJFHMm

By offering a reliable tool to induce the differentiation of immature #neuroblastoma cells, a new study could inform future research into the mechanisms of high-risk neuroblastoma and the ongoing quest for treatments. @BWHNeurology https://t.co/7CIj2Iqa5Y https://t.co/NTikaogofA

This week, scientists discover that a set of transcription factors called OVOLs can promote the dormancy of #BreastCancer cells, which is a key contributor to tumor relapse after treatment. @WeizmannScience https://t.co/3s0BTIV7VQ https://t.co/FCqb13S9yM

Constructing metabolic networks with #multiomics data in mice, a team shows that #obesity affects the liver’s response to starvation conditions by disrupting co-regulation by “hub” molecules and the temporal order of metabolic processes. @UTokyo_News_en https://t.co/e9m9NcFzes https://t.co/CBmr3ThFz8

This week’s new issue of #ScienceSignaling is out now! Scientists decode how obesity disrupts the liver’s ability to adapt to starvation in mice, a new study interrogates transcription factors that drive breast cancer dormancy, and more. https://t.co/02A5PlgHvQ https://t.co/WpZ17pDX5P

By offering a reliable tool to induce the differentiation of immature #neuroblastoma cells, a new study could inform future research into the mechanisms of high-risk neuroblastoma and the ongoing quest for treatments. @BWHNeurology https://t.co/7CIj2Iqa5Y https://t.co/RoPPtx5B5L

In a recent Review, scientists examine an emerging body of research implicating #SleepLoss as a metabolic disorder and discuss its impact on the metabolism of neurons, as well as parallels to neurodegenerative disorders. @SJUBiology https://t.co/DqAUVUocFM https://t.co/X7JhgQU6PO

The antipsychotic drug #thiothixene can revive macrophages’ ability to clear out dying cells—hinting similar compounds could offer therapies for disorders such as #atherosclerosis that involve the buildup of diseased tissue. @NickLeeper78 @StanfordVasc https://t.co/QdLbZoI9Sn https://t.co/IvPto0pBrk

In this week’s Editors’ Choice piece, we highlight a study by Zuhra and colleagues in @NatMetabolism, showing that protein modification by endogenous cyanide supports cell proliferation. Read a summary: https://t.co/mT5MZHuQTJ https://t.co/3uNFIVdCpF

This week, a team generates large datasets of proteins synthesized in motor neurons during development in mice and characterizes changes in the #translatome during synaptic pruning and the development of neuromuscular junctions. @BioMedSciEd https://t.co/Oiu7mDc8cq https://t.co/1gp0wqfwIc