Wei Wong
Deputy Editor at Science Magazine
Uncovering mechanisms in biology, gaining insights into physiology and disease.
Articles
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1 week ago |
science.org | Lien Nguyen |Wei Wong
Editors' ChoiceMETABOLISMWei Wong https://orcid.org/0009-0008-7154-4108 [email protected] Info & AffiliationsAbstractCovalent protein modification with endogenously produced cyanide supports mammalian cell proliferation. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Many biologically necessary substances become toxic at excessive amounts. Zuhra et al.
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1 week ago |
science.org | Lien Nguyen |Wei Wong |Satyaki Sengupta |Kevin Cho
Editor’s summaryNeuroblastoma is a pediatric cancer that originates from progenitor cells arising from the neural crest. A subtype of this cancer is characterized by the presence of immature mesenchymal (MES) cells, which are resistant to standard treatments, including retinoic acid therapy. Nguyen et al. screened small-molecule activators of the microRNA miR-124, which drives differentiation in neuroblastoma cells, and identified PP121, a drug that inhibits tyrosine and phosphoinositide kinases.
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Dec 10, 2024 |
radii.co | Mia Fan |Kimberly Yau |Jia Yan |Wei Wong
2024 was a banner year for Chinese dramas: Wong Kar-wai’s eagerly anticipated Blossoms Shanghai fused art house cinema with a Shanghainese soap opera, and a spate of other shows including To the Wonder demonstrated a perhaps surprising dedication to realism. Major acting talent equally at home on the silver screen, for example actresses Liu Yifei and Song Jia, took the lead in The Tale of Rose and She and Her Girls, respectively.
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Nov 15, 2024 |
onlinelibrary.wiley.com | Wei Wong |Tan Van Nguyen |Fahed Ahmad |Angela Koh
1 Background The region of Southeast Asia is a rapidly growing and developing part of the world. Geographically, it consists of 11 countries situated south of Mainland China, east of the Indian subcontinent and north of Australia. The 11 countries are (in alphabetical order) Brunei, Cambodia, Indonesia, Lao People's Democratic Republic, Malaysia, Myanmar, Philippines, Singapore, Thailand, Timor Leste, and Vietnam.
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Jun 18, 2024 |
science.org | Shane Wright |Kun Ping Lu |Wei Wong |Xiao Zhou
AbstractProtein phosphorylation is one of the most common mechanisms regulating cellular signaling pathways, and many kinases and phosphatases are proven drug targets. Upon phosphorylation, protein functions can be further regulated by the distinct isomerase Pin1 through cis-trans isomerization. Numerous protein targets and many important roles have now been elucidated for Pin1. However, no tools are available to detect or target cis and trans conformation events in cells.
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Don’t miss this week’s new issue of #ScienceSignaling! Scientists discover that an antipsychotic drug can revive macrophages’ ability to clear out dying cells, a new Review discusses how sleep loss is emerging as a metabolic disorder, and more. https://t.co/UsVK3OPz4o https://t.co/xnWYTbMNOQ
A study decodes what makes it possible for #RIPK3, a kinase that triggers cell death, to play a different role in neurons by protecting them from invading viruses, adding another dimension to the function of this kinase in #CellBiology. @UW_Immunology https://t.co/kBXOigbpL0 https://t.co/WDnISbyUgR
A team engineers a #biosensor that directly measures the activation of #GPCRs that couple to G-alpha-i without exogenously expressed receptors or #Gproteins and use it to probe interactions between neuropeptides and opioid receptors. @BUMedicine @MGMlab https://t.co/97av0WVRi9 https://t.co/4YcuXcyLp8