Lingjun Li

Jul 18, 2024 | nature.com | Di Zhang |Jinjun Gao |Zhijun Zhu |Pankaj K. Singh |Cornelius Rimayi |Carlos Moreno-Yruela | +7 more

AbstractLysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warburg effect and nuclear presence.

May 13, 2024 | nature.com | Fengfei Ma |Chao Xing |Lingjun Li |Wenzhi Sun

AbstractThe subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes, Sspo, Car3 and Spdef, that are highly expressed in the SCO.