Linjun Ao

Mar 1, 2024 | onlinelibrary.wiley.com | Raymond Noordam |Linjun Ao |Jasmijn Stroo |Leiden Laboratory

1 INTRODUCTION Sleep is a high-dimensional phenotype,1 is different for men and women, and is changing with increasing age.2 Disturbances in single dimensions of habitual sleep are increasingly recognized as important risk factors contributing to the onset of age-related diseases, including metabolic, cardiovascular and neurodegenerative diseases,3-7 COVID-19 and influenza susceptibility,8, 9 some types of cancer,10-12 and mortality.13 Mendelian randomization, which uses genetic variants...

May 30, 2023 | onlinelibrary.wiley.com | Linjun Ao |Diana van Heemst |Raymond Noordam |Leiden Laboratory

Sensitivity analysis To assess whether the dichotomous MetS definition loses information, we compared models fitted with MetS with models fitted with five continuous variables and with PCs (PC1 and PC2) using the Akaike information criterion (AIC) [(31)]. With respect to interpretation of the AIC, the lower the AIC, the better the model.