Diana van Heemst

Feb 18, 2024 | medrxiv.org | Vincent Q. Sier |Diana van Heemst |Paul H.A. Quax |J. Wouter Jukema

The authors have declared no competing interest. This work was supported by a Leiden University Medical Centre MD/PhD research grant to V.Q. Sier. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Nov 3, 2023 | nature.com | Diana van Heemst

AbstractThyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances in thyroid hormone action have been implicated in ageing and the development of age-related diseases. This Review will consider results from biomedical studies that have identified the importance of precise temporospatial regulation of thyroid hormone action for local tissue maintenance and repair.

Jul 25, 2023 | jclinepi.com | Leon Martens |Saskia le Cessie |Diana van Heemst |Raymond Noordam

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May 30, 2023 | onlinelibrary.wiley.com | Linjun Ao |Diana van Heemst |Raymond Noordam |Leiden Laboratory

Sensitivity analysis To assess whether the dichotomous MetS definition loses information, we compared models fitted with MetS with models fitted with five continuous variables and with PCs (PC1 and PC2) using the Akaike information criterion (AIC) [(31)]. With respect to interpretation of the AIC, the lower the AIC, the better the model.