Lluc Farrera-Soler

May 17, 2023 | nature.com | Cristina Díaz-Perlas |Lluc Farrera-Soler |Florence Pojer |Kelvin Lau |Benjamin Ricken |Christian-Benedikt Gerhold

AbstractCommon inflammatory disorders such as ulcerative colitis and Crohn’s disease are non-invasively diagnosed or monitored by the biomarker calprotectin. However, current quantitative tests for calprotectin are antibody-based and vary depending on the type of antibody and assay used. Additionally, the binding epitopes of applied antibodies are not characterized by structures and for most antibodies it is unclear if they detect calprotectin dimer, tetramer, or both.