Loredana Storelli

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Use of brain MRI and gene expression atlases to reconstruct the pathophysiology of autoimmune neurological disorders: The proof-of-concept of NMOSD

Dec 31, 2024 | journals.sagepub.com | Laura Cacciaguerra |Loredana Storelli |Elisabetta Pagani |Paolo Preziosa

IntroductionAs demonstrated in aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), knowledge of the pathophysiology of autoimmune neurological conditions is the most important step for the development of tailored treatments.1,2Summarizing, a pro-inflammatory environment and the peripheral loss of self-tolerance lead to the production of autoreactive IgGs by plasmablasts.

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