Lorenzo Scipioni

Jun 7, 2023 | nature.com | Albert S Agustinus |Stephanie Stransky |Lorenzo Scipioni |Jens Luebeck |Robert Myers |Britta Weigelt | +13 more

AbstractChromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers1,2,3,4, but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei5,6 and subsequent rupture of the micronuclear envelope7 profoundly disrupt normal histone post-translational modifications (PTMs), a phenomenon conserved across humans and mice, as well as in cancer and non-transformed cells.