Britta Weigelt

Jan 23, 2025 | nature.com | Fresia Pareja |Rohit Bhargava |Virginia F. Borges |Edi Brogi |Fatima Cardoso |Christine Desmedt | +16 more

AbstractSpecial histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges.

Mar 1, 2024 | acsjournals.onlinelibrary.wiley.com | Ying Liu |Britta Weigelt

CONFLICT OF INTEREST STATEMENT Ying L. Liu reports research funding from AstraZeneca, GSK, Artios Pharma, and Repare Therapeutics. Britta Weigelt reports research funding by Repare Therapeutics and employment of an immediate family member at AstraZeneca. REFERENCES 1, . Structure and function of the components of the human DNA mismatch repair system. Int J Cancer. 2006; 119(9): 2030-2035. doi:10.1002/ijc.22023 2, . Mismatch repair deficiency: the what, how and why it is important.

Jun 7, 2023 | nature.com | Albert S Agustinus |Stephanie Stransky |Lorenzo Scipioni |Jens Luebeck |Robert Myers |Britta Weigelt | +13 more

AbstractChromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers1,2,3,4, but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei5,6 and subsequent rupture of the micronuclear envelope7 profoundly disrupt normal histone post-translational modifications (PTMs), a phenomenon conserved across humans and mice, as well as in cancer and non-transformed cells.