Stephanie Stransky

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.

Sep 4, 2024 | nature.com | Carlos Garcia-Prieto |Anna Nordin |Stephanie Stransky |Damiana Álvarez-Errico |Ludvig Lizana |Jonathan Gilthorpe | +7 more

AbstractLysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation.

Dec 27, 2023 | analyticalsciencejournals.onlinelibrary.wiley.com | Edwin J Yoo |Julie Kim |Stephanie Stransky |Simon D. Spivack

REFERENCES , and . 2003. “Mass Spectrometry-Based Proteomics.” Nature 422 (6928): 198–207. https://doi.org/10.1038/nature01511 , , , , , and . 2013. “Exhaled Breath Condensate: A Comprehensive Update.” Clinical Chemistry and Laboratory Medicine 51 (7): 1343–1361. https://doi.org/10.1515/cclm-2012-0593 , , , , and . 2013. “Epidemiology of Lung Cancer.” Chest 143 (5): e1S–e29S. https://doi.org/10.1378/chest.12-2345 , , , and . 2011.

Jun 7, 2023 | nature.com | Albert S Agustinus |Stephanie Stransky |Lorenzo Scipioni |Jens Luebeck |Robert Myers |Britta Weigelt | +13 more

AbstractChromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers1,2,3,4, but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei5,6 and subsequent rupture of the micronuclear envelope7 profoundly disrupt normal histone post-translational modifications (PTMs), a phenomenon conserved across humans and mice, as well as in cancer and non-transformed cells.