Lorraine Southam

Nov 22, 2024 | cell.com | Georgia Katsoula |John Lawrence |Ana Luiza Arruda |Mauro Tutino |Petra Balogh |Lorraine Southam | +5 more

Keywords osteoarthritis RNA sequencing chondrocyte populations cell-type-specific expression endochondral ossification gene co-expression networks gene set analysis disease pathways Introduction Osteoarthritis is the most prevalent degenerative joint disorder, affecting over 500 million individuals worldwide.1 It is a complex disease, mainly characterized by loss of cartilage integrity and low-grade inflammation in tissues surrounding the joint.2 Management strategies focus on pain relief and...

May 20, 2024 | digitalcommons.library.tmc.edu | Ken Suzuki |Konstantinos Hatzikotoulas |Lorraine Southam |Henry Taylor

AbstractType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D.