Petra Balogh

Nov 22, 2024 | cell.com | Georgia Katsoula |John Lawrence |Ana Luiza Arruda |Mauro Tutino |Petra Balogh |Lorraine Southam | +5 more

Keywords osteoarthritis RNA sequencing chondrocyte populations cell-type-specific expression endochondral ossification gene co-expression networks gene set analysis disease pathways Introduction Osteoarthritis is the most prevalent degenerative joint disorder, affecting over 500 million individuals worldwide.1 It is a complex disease, mainly characterized by loss of cartilage integrity and low-grade inflammation in tissues surrounding the joint.2 Management strategies focus on pain relief and...

Dec 21, 2023 | biorxiv.org | Steven Woods |Kenny Roberts |Dinithi Sumanaweera |Petra Balogh

AbstractThe consistent production of in vitro chondrocytes that faithfully recapitulate in vivo development would be of great benefit for musculoskeletal disease modelling and regenerative medicine. Current efforts are often limited by off-target differentiation, resulting in a heterogeneous product. Furthermore, the lack of comparison to human embryonic tissue, precludes detailed evaluation of in vitro cells.