Louna Fruchard

Jan 8, 2025 | elifesciences.org | Tade Souaiaia |Clive J Hoggart |Paul O'Reilly |Louna Fruchard

eLife assessment The authors present a solid statistical framework for using sibling phenotype data to assess whether there is evidence for de novo or rare variants causing extreme trait values. Their valuable method is promising and will be of interest to researchers studying complex trait genetics.

Oct 5, 2024 | biorxiv.org | Louna Fruchard |Anamaria Babosan |André Carvalho |Manon Lang

AbstractTgt is the enzyme modifying the guanine (G) in tRNAs with GUN anticodon to queuosine (Q). tgt is required for optimal growth of Vibrio cholerae in the presence of sub-lethal aminoglycoside concentrations. We further explored here the role of the Q34 in the efficiency of codon decoding upon tobramycin exposure.

Nov 27, 2023 | biorxiv.org | Louna Fruchard |Anamaria Babosan |André Carvalho |Manon Lang

AbstractTgt is the enzyme modifying the guanine (G) in tRNAs with GUN anticodon to queuosine (Q). tgt is required for optimal growth of Vibrio cholerae in the presence of sub-lethal aminoglycoside concentrations. We further explored here the role of the Q in the efficiency of codon decoding upon tobramycin exposure.