Lu Cao

Nov 5, 2024 | onlinelibrary.wiley.com | Lu Cao |Dan Ou |Wei-xiang Qi |Cheng Xu

1 INTRODUCTION Postoperative radiotherapy (RT) plays an indispensable role in reducing recurrence and improving survival in breast cancer (BC) patients.1, 2 However, evidence has shown that radiation-induced heart disease (RIHD) would offset the survival benefits at different extents.3, 4 Unlike systemic treatments that are administered with fixed doses, radiation dose to the heart depends on predefined constraints and techniques.

Oct 13, 2024 | arxiv.org | Siyuan Li |Chen Feng |Lu Cao |Yue Zhang

Nov 22, 2023 | jci.org | Wenrui Zhang |Lu Cao |Jian Yang |Shuai Zhang

AbstractOxygen and nutrient deprivation are common features of solid tumors. Although abnormal alternative splicing (AS) has been found to be an important driving force in tumor pathogenesis and progression, the regulatory mechanisms of AS that underly the adaptation of cancer cells to harsh microenvironments remain unclear. Here, we found that hypoxia- and nutrient deprivation–induced asparagine endopeptidase (AEP) specifically cleaved DDX3X in a HIF1A-dependent manner.

Oct 7, 2023 | mdpi.com | Xin Hua |Lu Cao |Meng-Di Wang |Fang-Fang Duan

1. IntroductionGlobally, breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death among women [1]. Approximately 2.3 million new cases of breast cancer are diagnosed each year, and 685,000 people die from it [1]. In the treatment of breast cancer, neoadjuvant chemotherapy (NAC) has brought new hope with breakthroughs in effective treatment.