Mansi Pandya

Sep 24, 2024 | science.org | Moawiah M. Naffaa |Srestha Dasgupta |Amy Baek |Mansi Pandya

Editor’s summaryNeuron growth and survival are supported by neurotrophic factors. However, increases in the immature forms of neurotrophic factors—called proneurotrophins—are associated with neurodegeneration. Dasgupta et al. found that signaling by the proneurotrophin proNGF at the axon induced the retrograde degeneration of basal forebrain neurons.