Srestha Dasgupta

Sep 24, 2024 | science.org | Moawiah M. Naffaa |Srestha Dasgupta |Amy Baek |Mansi Pandya

Editor’s summaryNeuron growth and survival are supported by neurotrophic factors. However, increases in the immature forms of neurotrophic factors—called proneurotrophins—are associated with neurodegeneration. Dasgupta et al. found that signaling by the proneurotrophin proNGF at the axon induced the retrograde degeneration of basal forebrain neurons.

Sep 24, 2024 | science.org | Moawiah M. Naffaa |Srestha Dasgupta |Amy Baek

AbstractEarly exposure to cholesterol primes later atherosclerosis through phenotypic changes to resident-like arterial macrophages. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Animal models of atherosclerosis induce a hyperlipidemic state for a period of time before analysis of plaque deposition.

Sep 24, 2024 | science.org | Moawiah M. Naffaa |Srestha Dasgupta |Amy Baek |Henry H Yin

Editor’s summaryNeural stem cells in the lateral ventricles retain the ability to proliferate after birth and give rise to new neurons in the olfactory bulb. Naffaa and Yin elucidated the signaling cascade that links the activity of the cholinergic neurons located near these neural stem cells to the proliferation of the neural stem cells.