Marcy L’Etoile

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Articles

Representations of lipid nanoparticles using large language models for transfection efficiency prediction

May 29, 2024 | academic.oup.com | Ma Usa |Ontario Canada |Vu Thu |Marcy L’Etoile

Lipid nanoparticles (LNPs) are the most widely used vehicles for mRNA vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on the effectiveness of the mRNA payload. Several properties should be optimized to improve delivery and expression including biodegradability, synthetic accessibility and transfection efficiency (TE). To optimize LNPs we developed and tested models that enable the virtual screening of LNPs with high TE.
Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score | Critical Care | Full Text

Apr 21, 2023 | ccforum.biomedcentral.com | Marcy L’Etoile

Patients and settingIn the training cohort, the patients and the data are abstracted from the previously published REALISM (REAnimation Low Immune Status Marker) cohort study [11]. Briefly, this monocenter observational cohort study included critically ill patients with sepsis, trauma and burn patients between December 2015 and June 2018.

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