Vu Thu

May 29, 2024 | academic.oup.com | Ma Usa |Ontario Canada |Vu Thu |Marcy L’Etoile

Lipid nanoparticles (LNPs) are the most widely used vehicles for mRNA vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on the effectiveness of the mRNA payload. Several properties should be optimized to improve delivery and expression including biodegradability, synthetic accessibility and transfection efficiency (TE). To optimize LNPs we developed and tested models that enable the virtual screening of LNPs with high TE.