Sivaraman Natarajan

1 month ago | nature.com | Jiyuan Yang |Kaiwen Yu |Xu Yang |Sivaraman Natarajan |John Easton |Koon-Kiu Yan | +1 more

AbstractSpatial transcriptomics (ST) has advanced our understanding of tissue regionalization by enabling the visualization of gene expression within whole-tissue sections, but current approaches remain plagued by the challenge of achieving single-cell resolution without sacrificing whole-genome coverage.

May 25, 2024 | thehindu.com | Sivaraman Natarajan

I grew up in the ‘90s and the early 2000s when the norm was Doordarshan and mobile phones were just getting noticed. Evenings after school and college were spent lost in the world of books — one week, it was harsh Russian winters, next week, it was an adventure in the jungles of Africa. My favourite reading place was the terrace of our house.

Apr 22, 2024 | biorxiv.org | Richard H. Chapple |Xueying Liu |Sivaraman Natarajan |Margaret Alexander

AbstractNeuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a better understanding of the relationship between patient tumor heterogeneity and preclinical models. Here, we generated single-cell RNA-seq maps of neuroblastoma cell lines, patient-derived xenograft models (PDX), and a genetically engineered mouse model (GEMM).

Apr 14, 2023 | biorxiv.org | Richard H. Chapple |Xueying Liu |Sivaraman Natarajan |Margaret Alexander

AbstractNeuroblastoma is a common pediatric cancer, where preclinical studies have suggested chemotherapy resistance is driven by a mesenchymal-like gene expression program. However, the poor clinical outcomes imply we need a better understanding of the relationship between patient tumors and preclinical models. Here, we generated single-cell RNA-seq maps of neuroblastoma cell lines, patient-derived xenograft models (PDX), and a genetically engineered mouse model (GEMM).