Maria Cavinato

Feb 13, 2024 | febs.onlinelibrary.wiley.com | Maria Cavinato

GC gastric cancer GDF-15 growth/differentiation factor-15 ISR integrated stress response ROS reactive oxygen species SASP senescence-associated secretory phenotype TME tumor microenvironment UPRmt mitochondrial unfolded protein response Introduction Gastric cancer is a major global health concern and the second leading cause of cancer-related deaths worldwide.

Oct 25, 2023 | frontiersin.org | Akimichi Morita |Eleni Mavrogonatou |Maria Cavinato

1 IntroductionAging is a complex process that is characterized by a decline in physiological function and integrity. It involves macromolecular damage, impaired tissue renewal, and altered cellular signaling. This leads to tissue dysfunction, organ failure, and mortality (López-Otín et al., 2013; Zhang et al., 2015; Singh et al., 2019). Interestingly, skin aging can influence the aging phenotype in other organs.