Maria Raquel Maio

Oct 16, 2024 | alz-journals.onlinelibrary.wiley.com | Bahaaeddin Attaallah |Sofia Toniolo |Maria Raquel Maio |Masud Husain

1 INTRODUCTION Apathy (ie, diminished goal-directed behavior) is a prominent feature in several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and small vessel disease (SVD).1 It burdens patients and caregivers and is a marker of disease progression in some disorders.2, 3 In AD, up to 80% of patients develop apathy, even at early stages, making it a valuable preclinical marker.4 However, it remains poorly understood in AD, with limited behavioral...