Mariet Allen

Oct 22, 2024 | alz-journals.onlinelibrary.wiley.com | Richa Batra |Jan Krumsiek |Xue Wang |Mariet Allen

1 BACKGROUND Tau protein hyperphosphorylation and its abnormal accumulation in the brain is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP).1 The major clinical symptom of AD is dementia, which predominantly impairs memory,2 whereas PSP is a Parkinsonian movement disorder.3 Despite both representing tauopathies, these diseases have several key differences: First, AD is a dual proteinopathy, displaying deposition of...

Jun 20, 2024 | nature.com | Özkan İş |Xue Wang |Joseph S. Reddy |Yuhao Min |Elanur Yilmaz |Prabesh Bhattarai | +19 more

AbstractTo uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as main cell types of blood-brain-barrier gliovascular-unit. The majority of the vascular transcriptional changes were in pericytes.